Endocrine Abstracts

Introduction: Previous data from our group suggested a role for the GH/IGF1 axis in the pathophysiology of osteoporosis in thalassemia (Clin Endocrinol 69:202, 2008). The present study was aimed at evaluating the relationships between circulating IGFs and bone metabolism and density in a very large series of adult thalassemic patients.Study design: One hundred and thirty-nine patients affected by thalassemia major (mean age 32.3±7.87 years) underwen...